Vaccines for Cambodia
The checker on top is set on Cambodia: add Thailand or Vietnam as the next stop and your departure date to see the combined CDC list, the border rules and the prices.
Travel vaccines CDC lists for most or some travelers on this trip
5 vaccines
plus 2 to discuss and routine vaccines up to date
| Yellow fever | Required only if you arrive from a risk country (Cambodia) |
| Malaria | Prescription tablets for areas of Cambodia |
| Longest lead time | 28 days before departure (Hepatitis B, 2 doses (Heplisav-B)) |
| Published price, these vaccines | $1,405 median, $1,215 to $1,550 |
Levels from the CDC destination pages; age 35 used for the Japanese encephalitis schedule. A list to take to a doctor, nurse or pharmacist, not medical advice.
| Disease | CDC level | Where | Start at least | Median price per dose |
|---|---|---|---|---|
| Yellow fever | Required only if you arrive from a risk country | Cambodia | 10 days before | $269 |
| Hepatitis A | CDC: most travelers | Cambodia | Any time before | $109 |
| Hepatitis B | CDC: most travelers | Cambodia | 28 days before | $149 |
| Measles | CDC: most travelers | Cambodia | Ask | $115 |
| Typhoid | CDC: most travelers | Cambodia | 14 days before | $174 |
| Japanese encephalitis | CDC: some travelers | Cambodia | 14 days before | $375 |
| Chikungunya | CDC: may be considered | Cambodia | Any time before | $326 |
| Rabies | CDC: may be considered | Cambodia | 7 days before | $419 |
Compiled by Radif Partners · Method and sources · CDC page reviewed August 25, 2026, read October 24, 2026
The CDC page for Cambodia lists hepatitis A and typhoid for most travelers, and hepatitis B for unvaccinated travelers younger than 60 (those 60 and older may get it), on top of routine vaccines such as measles (MMR). Japanese encephalitis is for some travelers, rabies is to be discussed with a clinician because rabid dogs are commonly found, and chikungunya vaccination is generally not recommended. Malaria is mostly confined to pockets of rural and forested land: CDC reports no or negligible transmission in Phnom Penh, Siem Reap and the main temple complex at Angkor Wat, and lists four drugs, primaquine among them, for the forest areas. Cambodia asks no yellow fever certificate from travelers flying in from the US, but asks one from travelers aged 1 year or older arriving from a risk country, a layover of more than 12 hours included. At US county health departments the median price is $109 a dose for hepatitis A and $174 for the typhoid shot, $427 for the full hepatitis A series and the shot with visit fees.
Temples, cities and forest: three settings, one list
A typical first trip to Cambodia is Phnom Penh, then Siem Reap for the Angkor temples, sometimes a few nights on the coast near Kampot or on Koh Rong. Others cross from Thailand at Poipet, take the boat from Vietnam up the Mekong, or ride into the northeast toward Ratanakiri and Mondulkiri for forest treks. The vaccine list on the CDC page is the same for all of them; what changes is the malaria section, the Japanese encephalitis line and how close medical care is after a dog bite.
Hepatitis A, typhoid and hepatitis B
CDC lists hepatitis A for unvaccinated travelers aged one or more and typhoid for most travelers to Cambodia. Hepatitis B is recommended for unvaccinated travelers under 60, and those 60 and older may get it, the same wording as on the Thai page. For typhoid, the choice is between the shot, given at least 14 days before departure, and four oral capsules finished 7 days ahead. With two hepatitis A doses and visit fees, the shot version costs $375 to $560 at US county health departments and the oral version $320 to $410; the oral pack alone is $121 at the median against $174 for the shot. Hepatitis B adds $149 a dose when it applies.
Typhoid capsules or shot before Cambodia
Typhoid, oral capsules: when to start
13 days before
| Doses | 4 capsules, days 0, 2, 4, 6 (one pack) |
| Protection | 7 days after the last dose |
| Published price per dose | $121 median, $110 to $140 (6 departments) |
| Series, median total with fees | $143 ($139 to $190) |
Angkor Wat and the malaria map
Malaria in Cambodia is, in CDC's words, primarily isolated to pockets in rural and forested areas, with rare cases in non-forested areas. CDC reports no or negligible transmission in Phnom Penh, in Siem Reap and at the main temple complex of Angkor Wat. In areas with rare cases, the advice is insect bite precautions and mosquito avoidance, without tablets. In the rural and forested areas, CDC lists atovaquone-proguanil, doxycycline, primaquine and tafenoquine.
Primaquine is on the Cambodian list but not on the Thai or Vietnamese ones: P. vivax accounts for about 95% of cases, and chloroquine and mefloquine are both affected by resistance. Primaquine and tafenoquine both require a blood test for G6PD deficiency before a prescription, which the prescriber orders. For a week of forest trekking, the counts are 32 primaquine tablets (about $63 at the price pharmacies pay), 16 atovaquone-proguanil tablets (about $23) or 37 doxycycline tablets.
A week in forested Cambodia: tablets compared
Primaquine for 7 days in Cambodia
32 tablets
| CDC for this country | Prescription medicine for the areas listed |
| Drugs CDC lists here | Atovaquone-proguanil, Doxycycline, Primaquine, Tafenoquine |
| Start and stop | daily, from 2 days before to 7 days after the risk area |
Yellow fever: the age threshold is 1 year here
CDC does not recommend the yellow fever vaccine for Cambodia. The entry rule is for travelers arriving from a country with yellow fever risk, and two details differ from neighbors: the requirement starts at 1 year old, not 9 months as in Thailand, and an airport transit or layover of more than 12 hours in a risk country counts as arriving from it. A traveler coming from Bangkok, Ho Chi Minh City, London or Los Angeles shows nothing. One who flies in after a stint in Peru or Ghana does, and the shot ($269 at the median) has to be given at least 10 days before arrival.
Cambodia after a risk country
Yellow fever certificate for Cambodia
Required
| CDC vaccine advice | Not recommended |
| Who must show a certificate | Travelers arriving from risk countries |
| Valid from | 10 days after the shot, for life |
| Published price | $269 median, $226 to $360 |
Rabies, Japanese encephalitis and chikungunya
Dogs infected with rabies are commonly found in Cambodia, according to CDC, and rabies vaccines are typically available throughout most of the country after an exposure. Whether to take pre-exposure doses depends on the activities planned and on access to prompt care, a question CDC leaves to a healthcare provider; two doses cost $838 at the median. Japanese encephalitis is recommended by CDC for some travelers (moving there, a month or more in affected areas, frequent trips) and to be considered for shorter rural stays, hiking, camping or rooms without screens or nets; $375 a dose. Chikungunya vaccination is generally not recommended for Cambodia, and CDC asks all travelers to prevent mosquito bites, which also matters under its global dengue notice. The Southeast Asia page compares Cambodia with its neighbors.
What CDC says for Cambodia, word for word
Source: CDC, Travelers' Health destination page for Cambodia, page last reviewed August 25, 2026, read on October 24, 2026. The text is reproduced without change; it is available free of charge on cdc.gov. Its use here does not imply endorsement by CDC, ATSDR, HHS or the United States Government.
Travel notices: Level 1, Global Dengue (September 3, 2026) · Level 1, Global Measles (May 28, 2025)
| Disease | CDC wording |
|---|---|
| Routine vaccines | Make sure you are up-to-date on all routine vaccines before every trip. Some of these vaccines include • Chickenpox (Varicella) • Diphtheria-Tetanus-Pertussis (DTaP, Tdap, or Td) • Flu (influenza) • Measles-Mumps-Rubella (MMR) • Polio • Shingles |
| COVID-19 | All eligible travelers should be up to date with their COVID-19 vaccines. Please see Your COVID-19 Vaccination for more information. |
| Hepatitis A | Recommended for unvaccinated travelers one year old or older going to Cambodia. Infants 6 to 11 months old should also be vaccinated against Hepatitis A. The dose does not count toward the routine 2-dose series. Travelers allergic to a vaccine component should receive a single dose of immune globulin, which provides effective protection for up to 2 months depending on dosage given. Unvaccinated travelers who are over 40 years old, are immunocompromised, or have chronic medical conditions planning to depart to a risk area in less than 2 weeks should get the initial dose of vaccine and at the same appointment receive immune globulin. |
| Hepatitis B | Recommended for unvaccinated travelers younger than 60 years old traveling to Cambodia. Unvaccinated travelers 60 years and older may get vaccinated before traveling to Cambodia. |
| Typhoid | Recommended for most travelers. Typhoid vaccine is not 100% effective. Practicing safe food and water habits, including washing hands at key times, can also help prevent typhoid fever. |
| Yellow Fever | CDC recommendations: Vaccine is not recommended. Country entry requirements: • Direct travel from United States: Vaccine is not required. • Travel from countries with risk for YF virus transmission: Vaccine is required for travelers ≥1 year old; this includes >12-hour airport transits or layovers in countries with risk for YF virus transmission. Updated April 23, 2025 See footnotes |
| Malaria | CDC recommends that travelers going to certain areas of Cambodia take prescription medicine to prevent malaria. Depending on the medicine you take, you will need to start taking this medicine multiple days before your trip, as well as during and after your trip. Talk to your doctor about which malaria medication you should take. Transmission areas • Primarily isolated to pockets in rural and forested areas • Rare cases in non-forested areas • No (or negligible) malaria transmission in the cities of Phnom Penh (the capital) and Siem Reap • No (or negligible) malaria transmission at the main temple complex at Angkor Wat Drug resistance • Chloroquine and mefloquine Species • P. vivax (95%) • P. falciparum (5%) • P. malariae and P. knowlesi (rare) Recommended chemoprophylaxis • Rural and forested areas: Atovaquone-proguanil, doxycycline, primaquine, tafenoquine • Areas with rare cases: No chemoprophylaxis recommended (insect bite precautions and mosquito avoidance only) Updated April 23, 2025 See footnotes |
| Japanese Encephalitis | Recommended for travelers who • Are moving to an area with Japanese encephalitis to live • Spend long periods of time, such as a month or more, in areas with Japanese encephalitis • Frequently travel to areas with Japanese encephalitis Consider vaccination for travelers • Spending less than a month in areas with Japanese encephalitis but will be doing activities that increase risk of infection, such as visiting rural areas, hiking or camping, or staying in places without air conditioning, screens, or bed nets • Going to areas with Japanese encephalitis who are uncertain of their activities or how long they will be there Not recommended for travelers planning short-term travel to urban areas or travel to areas with no clear Japanese encephalitis season. |
| Rabies | Dogs infected with rabies are commonly found in Cambodia. If rabies exposures occur while in Cambodia, rabies vaccines are typically available throughout most of the country. Rabies pre-exposure vaccination considerations include whether travelers 1) will be performing occupational or recreational activities that increase risk for exposure to potentially rabid animals and 2) might have difficulty getting prompt access to safe post-exposure prophylaxis. Please consult with a healthcare provider to determine whether you should receive pre-exposure vaccination before travel. For more information, see country rabies status assessments. |
| Chikungunya | All travelers should take steps to prevent mosquito bites. Chikungunya vaccination is generally not recommended. Travelers who wish to consider vaccination can visit “What to consider before traveling” on the chikungunya vaccines page to learn more. |
| Measles | Cases of measles are on the rise worldwide. Travelers are at risk of measles if they have not been fully vaccinated at least two weeks prior to departure, or have not had measles in the past, and travel internationally to areas where measles is spreading. All international travelers should be fully vaccinated against measles with the measles-mumps-rubella (MMR) vaccine, including an early dose for infants 6–11 months, according to CDC’s measles vaccination recommendations for international travel. |
| Monkeypox | Monkeypox vaccination is recommended for any adult who anticipates any of the following activities during travel: • Sexual or intimate contact with a new partner • Sexual or intimate contact at a commercial sex venue, like a sex club or bathhouse • Sexual or intimate contact in exchange for money, goods, drugs, or other trade • Sexual or intimate contact in association with a large public event, such as a rave, party, or festival Get your first monkeypox vaccine at least 6 weeks before traveling if you can, or as far as possible before travel if fewer than 6 weeks before you leave. Two doses of vaccine, given 4 weeks apart, are recommended. After completing your first and second vaccine doses it takes about 2 more weeks to get the best protection against monkeypox. Whether or not you've been vaccinated, continue to take steps to reduce your risk of getting monkeypox while you are away. |